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Related Experiment Video

Updated: Nov 23, 2025

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications

Published on: April 30, 2014

Editorial Commentary: Remember the Risk Factors During Individualized, Anatomic, Value-Based Anterior Cruciate

Freddie H Fu¹, Kevin J Byrne¹, Brian M Godshaw¹

¹University of Pittsburgh School of Medicine.

Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association

|January 1, 2021

Summary

Anterior cruciate ligament (ACL) reconstruction failure stems from technical, traumatic, or biologic causes, with technical errors like tunnel malposition being most frequent. Addressing risk factors and individualizing treatment is key for successful ACL revision surgery.

Area of Science:

Orthopedic surgery
Sports medicine
Biomechanical engineering

Background:

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Anterior cruciate ligament (ACL) reconstruction failure is a significant clinical challenge.

Failure etiologies are broadly categorized into technical, traumatic, and biologic factors.

Technical errors, particularly tunnel malposition, are the most prevalent cause of ACL reconstruction failure.