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What Is T+? A Gordian Knot of Tracers, Thresholds, and Topographies
Victor L Villemagne1,2,3, Brian J Lopresti4, Vincent Doré5,6
1Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania victor.villemagne@pitt.edu.
Abstract:
In this review we examine, in the context of the amyloid, tau, and neurodegeneration framework, the available evidence and potential alternatives on how to establish tau positivity (T+) for multiple tau-imaging tracers in order to reach a consensus on normal and abnormal tau imaging values that can be universally implemented in clinical research and therapeutic trials.
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