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Mesoporous bioactive glass composition effects on degradation and bioactivity
M Schumacher1, P Habibovic1, S van Rijt1
1Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, the Netherlands.
Bioactive Materials
|January 1, 2021
Summary
Mesoporous bioactive glasses (MBGs) for regenerative medicine have tunable bioactivity and degradation. Stoichiometry controls these properties, allowing tailored material selection for specific applications.
Area of Science:
- Materials Science
- Biomaterials Engineering
- Regenerative Medicine
Background:
- Mesoporous bioactive glasses (MBGs) are vital for regenerative medicine due to their bioactivity and degradability.
- MBG properties like surface area, pore structure, and volume are sensitive to synthesis parameters and glass composition.
- A systematic study of MBG properties across a wide compositional range was lacking.
Purpose of the Study:
- To investigate the impact of varying SiO2, CaO, and P2O5 content on MBG properties.
- To analyze mesopore characteristics, degradability, and bioactivity of synthesized MBGs.
- To establish relationships between glass stoichiometry and MBG performance for targeted applications.
Main Methods:
- Synthesized 24 MBG compositions in the SiO2-CaO-P2O5 system.
- Varied SiO2 (60-90 mol%) and CaO/P2O5 (0-40 mol%) while keeping other parameters constant.
- Analyzed mesopore characteristics, degradation, and bioactivity in simulated body fluid.
Main Results:
- Mesopore formation required >60% SiO2, independent of CaO/P2O5.
- Mesopore arrangement varied with SiO2 content; size was unaffected.
- Degradation and bioactivity (hydroxyapatite or calcite formation) were dependent on glass stoichiometry.
Conclusions:
- Glass stoichiometry significantly controls MBG degradation and bioactivity.
- Structural parameters of MBGs remain relatively unaffected by stoichiometry changes.
- This allows for the targeted design of MBGs for specific regenerative medicine needs.
