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Related Experiment Videos

Experimental allergic encephalomyelitis: a neurourological study.

L Germain1, C Galeano, J Lamarche

  • 1Department of Physiology, University of Sherbrooke, School of Medicine, Quebec, Canada.

Experimental Neurology
|February 1, 1988
PubMed
Summary
This summary is machine-generated.

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Experimental allergic encephalomyelitis (EAE) causes significant neurourological disturbances, including reduced bladder capacity and urethral pressure. Spinal cord inflammation correlates with these urinary system dysfunctions in rabbits.

Area of Science:

  • Neuroscience
  • Immunology
  • Urology

Background:

  • Experimental allergic encephalomyelitis (EAE) is an animal model for multiple sclerosis.
  • Perivascular inflammation in the central nervous system can lead to various neurological deficits.

Purpose of the Study:

  • To investigate the neurourological disturbances affecting the urinary system during the acute phase of EAE.
  • To correlate central nervous system inflammation with observed functional changes.

Main Methods:

  • A controlled study involving 46 New Zealand male rabbits inoculated with an encephalitogenic preparation.
  • Assessment of urinary function using cystosphincterograms.
  • Histopathological examination of the central nervous system, including hematoxylin-eosin and Luxol Fast Blue staining.

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Main Results:

  • Rabbits with EAE showed significantly reduced mean vesical capacity, maximum urethral pressure, and mean urethral pressure.
  • A negative correlation was found between spinal cord inflammation and urethral pressures.
  • Supra-mesencephalic inflammation was negatively correlated with mean vesical capacity.

Conclusions:

  • The perivascular inflammatory process in EAE significantly impacts bladder capacity and urethral function.
  • Spinal cord and supra-mesencephalic inflammation are associated with these neurourological deficits.
  • EAE serves as a relevant model for studying inflammatory-induced urological dysfunction.