Related Experiment Video
Updated: Nov 23, 2025

Measuring Rates of Herbicide Metabolism in Dicot Weeds with an Excised Leaf Assay
Published on: September 7, 2015
Regulation of insect P450s in response to phytochemicals
Xianchun Li1, Zhongyuan Deng2, Xuewei Chen2
1Department of Entomology and BIO5 Institute, University of Arizona, Tucson, AZ 85721, United States.
Abstract:
Insect herbivores use phytochemicals as signals to induce expression of their phytochemical-detoxifying cytochrome P450 monooxygenases (P450s). The regulatory cascades that transduce phytochemical signals to enhanced expression of P450s are the focus of this review. At least seven signaling pathways, including RTK/MAPK, GPCR/CREB, GPCR/NFκB, ROS/CncC/Keap1, AhR/ARNT, cytosol NR, and nucleus-located NR, may be involved in phytochemical induction of P450s. Constitutive overexpression, overphosphorylation, and/or activation of one or more effectors in the corresponding pathway are common causes of P450 overexpression that lead to phytochemical or insecticide resistance. Future research should pay more attentions to the starting point of each pathway, the number of pathways and their cross talk for a given phytochemical, and the pathways for downregulation of P450s.
More Related Videos
Related Concept Videos
Drug Metabolism: Phase I Reactions
Regulation of Metabolism
Drug Metabolism: Phase II Reactions
Phase I Reactions: Oxidation of Aliphatic and Aromatic Carbon-Containing Systems
Oxidation reactions are fundamental in aromatic carbon-containing systems. An example is the hydroxylation of phenobarbital, a process that transforms it into...
Pharmacokinetics: Drug–Drug Interactions
Biological Clocks and Seasonal Responses

