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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Cyclodextrins based delivery systems for macro biomolecules.

Jiang Liu1, Xin Ding1, Yupeng Fu1

  • 1China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, 300457, Tianjin, China.

European Journal of Medicinal Chemistry
|January 1, 2021
PubMed
Summary
This summary is machine-generated.

Cyclodextrins (CDs) offer promising delivery systems for macro biomolecules like proteins and nucleic acids (NAs). This review highlights CDs

Keywords:
CyclodextrinsDrug delivery systemsNucleic acidsParticlesProteins

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Area of Science:

  • Biomolecular Chemistry
  • Drug Delivery Systems
  • Nanotechnology

Background:

  • Macro biomolecules, including proteins and nucleic acids (NAs), are crucial for regulating biological functions and hold therapeutic potential.
  • Protecting these sensitive molecules from degradation during delivery to target sites is a significant challenge in developing effective therapies.
  • Cyclodextrins (CDs) have demonstrated success in small molecule drug delivery, but their application in macro biomolecule delivery requires further systematic review.

Purpose of the Study:

  • To systematically review and analyze cyclodextrin (CD)-based delivery systems for macro biomolecules, with a particular focus on proteins.
  • To summarize notable examples of CD-mediated delivery for various proteins and nucleic acids.
  • To highlight the potential of CDs in developing advanced therapeutic strategies using biomolecules.

Main Methods:

  • Literature review of studies employing cyclodextrins for the delivery of proteins and nucleic acids.
  • Categorization of delivery strategies based on release profiles (slow, stimulated, targeted) and carrier types (CD-polymers, CD-cluster monomers).
  • Analysis of specific examples including insulin, lysozyme, bovine serum albumin (BSA), green fluorescent protein (GFP), IgG, and siRNA.

Main Results:

  • CD-based systems facilitate controlled release (slow, stimulated, targeted) of various proteins like insulin, lysozyme, BSA, GFP, and IgG.
  • Cationic CD-polymers and CD-cluster monomers serve as effective carriers for nucleic acids (NAs).
  • Advanced CD-based carriers include multicomponent targeted systems and virus-like RNA assembly methods for siRNA delivery.

Conclusions:

  • Cyclodextrins are versatile platforms for developing sophisticated delivery systems for therapeutic proteins and nucleic acids.
  • CD-based strategies effectively address the challenge of protecting macro biomolecules from degradation, enabling their functional delivery.
  • This review underscores the significant potential of cyclodextrin nanotechnology in advancing modern therapies utilizing biomacromolecules.