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Imaging Studies II: Ultrasonography01:24

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IntroductionUltrasonography, or renal ultrasound, is a noninvasive medical imaging technique that uses high-frequency sound waves to visualize the kidneys, ureters, bladder, and surrounding tissues.Indications for Urinary System UltrasonographyUrinary system ultrasonography is indicated in various clinical scenarios, such as:Kidney Stones (Urolithiasis): To detect and monitor the size and presence of kidney or urinary tract stones.Hydronephrosis: To assess the dilation of the renal pelvis and...
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Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...
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Cardiovascular magnetic resonance imaging, or CMRI, is a non-invasive diagnostic test that employs a magnetic field and radiofrequency waves to create precise images of the heart and arteries. It provides comprehensive information about cardiac anatomy, function, perfusion, and tissue characterization without ionizing radiation.IndicationsCMRI diagnoses various heart conditions, including tissue damage from heart attacks, ischemic heart disease, myocarditis, aortic issues (tears, aneurysms,...
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Related Experiment Video

Updated: Nov 23, 2025

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
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Stroke core revealed by tissue scattering using spatial frequency domain imaging.

Smrithi Sunil1, Sefik Evren Erdener2, Xiaojun Cheng1

  • 1Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA.

Neuroimage. Clinical
|January 1, 2021
PubMed
Summary
This summary is machine-generated.

Optical coherence tomography (OCT) and spatial frequency domain imaging (SFDI) accurately map stroke core extent in mice. These optical techniques enable longitudinal studies of stroke recovery without immediate sacrifice.

Keywords:
Optical coherence tomographyOptical scatteringSpatial frequency domain imagingStrokeTTC staining

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Area of Science:

  • Neuroscience
  • Biomedical Optics
  • Stroke Research

Background:

  • Ischemic stroke causes brain tissue injury and behavioral deficits.
  • Accurate infarct extent estimation is crucial for studying stroke recovery.
  • Current methods often require histological analysis, limiting longitudinal studies.

Purpose of the Study:

  • Establish optical coherence tomography (OCT) as a reliable indicator of the stroke core.
  • Introduce spatial frequency domain imaging (SFDI) for mesoscopic infarct extent measurement.
  • Utilize OCT and SFDI for longitudinal monitoring of stroke progression and recovery.

Main Methods:

  • Correlating OCT signal attenuation with infarct size determined by triphenyl-tetrazolium chloride (TTC) staining.
  • Employing SFDI to measure infarct spatial extent by analyzing changes in optical scattering.
  • Monitoring stroke progression in acute and sub-acute phases using both OCT and SFDI.

Main Results:

  • OCT signal attenuation reliably indicates the stroke core.
  • SFDI accurately measures infarct spatial extent by exploiting stroke-induced optical scattering changes.
  • OCT and SFDI show high spatial overlap in infarct location estimation during recovery.

Conclusions:

  • OCT and SFDI are effective optical tools for assessing stroke core and infarct extent.
  • SFDI enables mesoscopic, longitudinal studies of stroke recovery without acute sacrifice.
  • These optical methods advance the understanding of stroke pathophysiology and recovery mechanisms.