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Metformin-induced weight loss in patients with or without type 2 diabetes/prediabetes: A retrospective cohort study
Tariq Chukir1, Lindsay Mandel2, Beverly G Tchang3
1Department of Medicine, Division of Endocrinology, Diabetes, and Metabolism, Weill Cornell Medicine and NewYork-Presbyterian Hospital, 525 E 68thSt. F20, New York, NY, 10065, USA.
Abstract:
It is unknown whether weight loss outcomes differ with metformin monotherapy in patients with obesity with or without type 2 diabetes (T2DM)/prediabetes (PreDM). In this retrospective study, 6- or 12-month weight loss outcomes were compared in 222 patients with or without T2DM/preDM who completed metformin monotherapy. Average weight loss was similar between groups, euglycemic vs. T2DM/preDM (6 months: 6.5 [6.0%] vs. 6.5 [6.1%] p = 0.97; 12 months: 7.4 [6.2%] vs. 7.3 [7.7%], p = 0.92). Categorical weight losses (≥5% and ≥10% of baseline weight) were also similar. Comparable clinically significant weight loss was achieved with metformin monotherapy in patients with obesity with or without T2DM/PreDM.
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