Effect of clofibrate and calcium in type II A hyperlipoproteinaemia

In type II A hyperlipoproteinaemia, treatment with cholestyramine (12 g), calcium clofibrate (2 g) and a combination of calcium clofibrate and calcium carbonate (2 + 2 g) reduced the cholesterol concentration. The combination of calcium and clofibrate was at least as effective as cholestyramine. Calcium clofibrate decreased very low density and low density lipoprotein cholesterol, triglycerides and phospholipids, whereas no changes were found in high density lipoproteins. Cholestyramine decreased low density lipoprotein lipids.