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Stem cell-based models and therapies: a key approach into schizophrenia treatment

Bagher Larijani1, Peyvand Parhizkar Roudsari2, Mahdieh Hadavandkhani3

  • 1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Cell and Tissue Banking
|January 2, 2021
PubMed

Insights

Stem cell therapies offer novel treatment strategies for psychiatric disorders like schizophrenia. Stem cell-based models, particularly induced pluripotent stem cells, provide better alternatives to animal models for preclinical research.

Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Psychiatric disorders, including schizophrenia, cause significant distress, disability, and economic burden.
  • Current treatments for psychiatric disorders are often suboptimal, necessitating the exploration of novel therapeutic approaches.
  • Genetic and environmental factors contribute to the development of these complex disorders.

Purpose of the Study:

  • To highlight the potential of stem cell therapies as a novel treatment strategy for psychiatric disorders.
  • To emphasize the importance of appropriate preclinical models for evaluating stem cell-based therapies.
  • To discuss the utility of stem cell-based models, specifically induced pluripotent stem cells, as alternatives to animal models for schizophrenia research.

Main Methods:

  • Review of current literature on stem cell therapies for psychiatric disorders.
  • Evaluation of the limitations of traditional animal models in mimicking psychiatric disorder pathophysiology.
  • Exploration of induced pluripotent stem cells as suitable in vitro models for disease modeling and drug screening.

Main Results:

  • Stem cell therapies show promise as a regenerative medicine approach for psychiatric disorders.
  • Induced pluripotent stem cells offer a more relevant platform for studying disease mechanisms and testing therapeutic interventions compared to animal models.
  • Preclinical evaluation using stem cell-based models is crucial for ensuring the safety and efficacy of novel treatments.

Conclusions:

  • Stem cell-based models, particularly induced pluripotent stem cells, are valuable tools for advancing regenerative medicine for schizophrenia.
  • Further research utilizing these models is essential to develop effective and safe stem cell therapies for severe psychiatric conditions.
  • The transition to stem cell-based models represents a significant advancement in the preclinical evaluation of psychiatric disorder treatments.
Keywords:
Disease modelsInduced pluripotent stem cellsPsychiatric disordersRegenerative medicinesSchizophreniaStem cell transplantation

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