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Differential serological and neutralizing antibody dynamics after an infection by a single SARS-CoV-2 strain
Emmanuelle Billon-Denis1,2, Audrey Ferrier-Rembert1, Annabelle Garnier1
1Microbiology and Infectious Diseases Department, Institut de Recherche Biomédicale des Armées (IRBA), 1 place Général Valérie André, 91220, Brétigny sur Orge, France.
Background:
We report here the case of two coworkers infected by the same SARS-CoV-2 strain, presenting two different immunological outcomes.
Case:
One patient presented a strong IgG anti-receptor-binding domain immune response correlated with a low and rapidly decreasing titer of neutralizing antibodies. The other patient had a similar strong IgG anti-receptor-binding domain immune response but high neutralizing antibody titers.
Discussion And Conclusion:
Thus, host individual factors may be the main drivers of the immune response varying with age and clinical severity.
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