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Correlation between increased immune checkpoint molecule expression and refractoriness to blinatumomab evaluated by

Takahiro Kobayashi1, Kumi Ubukawa2, Masumi Fujishima2

  • 1Department of Hematology, Nephrology and Rheumatology, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita City, Akita, 010-8543, Japan. takahiro@med.akita-u.ac.jp.

International Journal of Hematology
|January 2, 2021
PubMed
Summary

Blinatumomab treatment response in B-cell acute lymphoblastic leukemia may depend on T cell immune checkpoint molecules. High levels of PD-1, Tim-3, and TIGIT in T cells correlate with poor response.

Keywords:
B-cell precursor acute lymphoblastic leukemiaBlinatumomabImmune checkpoint moleculesRegulatory T cells

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