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Updated: Nov 23, 2025

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STIM2: Redox-sensor and effector of the (tumor) microenvironment
Albrecht Schwab1, Thorsten Loeck1, Karolina Najder-Nalepa1
1Institut für Physiologie II, Robert-Koch-Str. 27b, D-48149, Münster, Germany.
Abstract:
Ion channels and their associated proteins are at the interface between the cytosol and the extracellular space. In cancer, this allows them to sense and transduce physico-chemical cues from the tumor microenvironment and thereby shape the aggressive cell behavior. In a recent paper Gibhardt et al. provide profound mechanistic insight how STIM2, an integral component of the store-operated Ca2+ entry (SOCE) mechanism in melanoma cells, is redox-regulated.
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