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Updated: Nov 23, 2025

Isolation and Analysis of Hematopoietic Stem Cells from the Placenta
Published on: June 24, 2008
Maternal Hematologic Neoplasms during Pregnancy: Histologic Findings in the Placenta
Ashlie E Rubrecht1, Robert P Seifert1, Archana Shenoy2
1University of Florida, Department of Pathology, Immunology, and Laboratory Medicine, Gainesville, FL, USA.
Abstract:
Placental metastasis of maternal neoplasms is well documented in solid tumors, unlike hematologic neoplasms. We reviewed placental findings from deliveries complicated by maternal hematologic neoplasms exploring the prevalence and patterns of placental transmission and insufficiency. In the 8-yr study period, 11 cases were analyzed. Acute myeloid leukemia was the most common diagnosis (4/11, 36%). Seven cases (63%) showed no evidence of placental spread of neoplasm, while four cases (36%) showed placental spread, restricted to the maternal compartment. Maternal vascular malperfusion was documented in 8/11 (72%) cases. Neonatal follow up was available in 10 cases, all children were alive and well.
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