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Essential roles of the dystrophin-glycoprotein complex in different cardiac pathologies
Isela C Valera1, Amanda L Wacker1, Hyun Seok Hwang1
1Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, USA.
Advances in Medical Sciences
|January 2, 2021
Summary
The dystrophin-glycoprotein complex (DGC) remodels during heart disease, impacting muscle membrane stability. Understanding DGC remodeling offers therapeutic potential for various cardiac conditions beyond muscular dystrophies.
Area of Science:
- Cardiovascular Biology
- Muscle Physiology
- Molecular Medicine
Background:
- The dystrophin-glycoprotein complex (DGC) is crucial for sarcolemma stability and mechanical force transmission.
- Genetic defects in DGC proteins cause muscular dystrophies, highlighting its role in muscle health.
- The DGC is increasingly recognized for its dynamic remodeling in response to cardiac stress.
Purpose of the Study:
- To review the dynamic remodeling of the DGC in cardiac disease.
- To explore DGC remodeling as a common factor across various heart conditions.
- To discuss the therapeutic potential of targeting the DGC for heart disorders.
Main Methods:
- Literature review of studies on DGC function and remodeling in cardiac disease.
- Analysis of DGC alterations in response to genetic causes and pathogenic insults.
- Synthesis of current knowledge on DGC's role in heart health and disease.
Main Results:
- DGC remodeling is a common feature in diseases affecting heart function.
- Pathogenic processes, including ischemia-reperfusion and myocarditis, alter DGC protein abundance.
- DGC links the cytoskeleton to the extracellular matrix, essential for mechanical stability.
Conclusions:
- DGC remodeling is a significant factor in diverse heart diseases.
- Targeting the DGC may offer novel therapeutic strategies for cardiac conditions.
- Further research into DGC's role can benefit clinical management of heart disease.
Keywords:
Acquired cardiomyopathiesCardiac injury and regenerationDystrophin-glycoprotein complexGenetic cardiomyopathiesMuscular dystrophiesMore Related Videos
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