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Use of Natural Compounds as a Potential Therapeutic Agent Against COVID-19

Shadma Wahab1, Irfan Ahmad2, Safia Irfan3

  • 1Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Saudi Arabia.

Current Pharmaceutical Design
|January 3, 2021
PubMed

Insights

Natural products offer potential treatments for the novel coronavirus (SARS-CoV-2). This review discusses compounds and derivatives that may combat emerging coronavirus mutants and treat severe respiratory diseases.

Area of Science:

  • Pharmacology
  • Virology
  • Natural Products Chemistry

Background:

  • The 2019 novel coronavirus (2019-nCoV), now known as Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), causes a global health crisis with no current vaccine or drug.
  • SARS-CoV-2 primarily attacks the respiratory system, leading to lung lesions and severe pneumonia.

Purpose of the Study:

  • To review the current status of natural compounds and their derivatives as potential therapeutic agents against various Coronaviruses (CoVs).
  • To explore the role of natural products in developing new drugs to combat emergent SARS-CoV-2 variants.

Main Methods:

  • Literature review of existing studies on natural products and their antiviral activities.
  • Analysis of documented effects of natural compounds against different species of Coronaviruses.

Main Results:

  • Natural products have historically played a vital role in drug discovery and development.
  • Several natural compounds and their derivatives have demonstrated activity against different CoV species.

Conclusions:

  • Natural products represent a promising source for developing novel antiviral drugs against SARS-CoV-2.
  • Further research into these compounds could lead to effective treatments for coronavirus disease and its emergent mutants.
Keywords:
AntiviralsCOVID19SARS-CoV-2dietary supplementsnatural productsphytotherapy

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