Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Conjugated Proteins02:50

Conjugated Proteins

24.3K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
24.3K
Cancer Vaccines01:30

Cancer Vaccines

628
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
628
Synthetic Biology02:55

Synthetic Biology

5.2K
Synthetic biology is an interdisciplinary science that involves using principles from disciplines such as engineering, molecular biology, cell biology, and systems biology. It involves remodeling existing organisms from nature or constructing completely new synthetic organisms for applications such as protein or enzyme production, bioremediation, value-added macromolecule production, and the addition of desirable traits to crops, to name a few.
Golden rice
Golden rice is a genetically modified...
5.2K
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

430
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
430
Vaccinations01:51

Vaccinations

49.4K
Overview
49.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis and In Vivo Immunological Evaluation of Novel Saponin-Antigen Conjugates Incorporating Tumor-Associated Carbohydrate and Peptide Epitopes.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Design, synthesis and immunological evaluation of CRM<sub>197</sub>-based immunogens functionalized with synthetic scaffolds displaying a tumor-associated MUC1 glycopeptide.

Biomaterials science·2025
Same author

The microbiota metabolite, phloroglucinol, confers long-term protection against inflammation.

Gut microbes·2024
Same author

Development of a New Vaccine Adjuvant System Based on the Combination of the Synthetic TLR4 Agonist FP20 and a Synthetic QS-21 Variant.

Journal of medicinal chemistry·2024
Same author

Development of synthetic, self-adjuvanting, and self-assembling anticancer vaccines based on a minimal saponin adjuvant and the tumor-associated MUC1 antigen.

Chemical science·2023
Same author

Chemical biology tools to interrogate the roles of <i>O</i>-GlcNAc in immunity.

Frontiers in immunology·2023
Same journal

Advances in virtual screening.

Drug discovery today. Technologies·2024
Same journal

Integration of virtual and physical screening.

Drug discovery today. Technologies·2024
Same journal

A technical overview of supercritical fluid chromatography-mass spectrometry (SFC-MS) and its recent applications in pharmaceutical research and development.

Drug discovery today. Technologies·2021
Same journal

Mass spectrometry based approaches and strategies in bioanalysis for qualitative and quantitative analysis of pharmaceutically relevant molecules.

Drug discovery today. Technologies·2021
Same journal

Drug discovery from natural products using affinity selection-mass spectrometry.

Drug discovery today. Technologies·2021
Same journal

Editorial for the role(s) of MS in drug research and development.

Drug discovery today. Technologies·2021
See all related articles

Related Experiment Video

Updated: Nov 23, 2025

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
13:36

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

10.6K

Synthetic carbohydrate-based HIV-1 vaccines.

Iñaki Bastida1, Alberto Fernández-Tejada2

  • 1Chemical Immunology Lab, CIC bioGUNE, Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 801A, 48169 Derio, Bizkaia, Spain.

Drug Discovery Today. Technologies
|January 3, 2021
PubMed
Summary
This summary is machine-generated.

Developing a synthetic carbohydrate-based vaccine against HIV-1 is crucial. This research focuses on creating epitope mimics to elicit broadly neutralizing antibodies (bnAbs) for an effective HIV vaccine.

More Related Videos

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
13:53

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Published on: December 19, 2020

5.2K
Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

7.8K

Related Experiment Videos

Last Updated: Nov 23, 2025

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
13:36

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

10.6K
Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes
13:53

Homogeneous Glycoconjugate Produced by Combined Unnatural Amino Acid Incorporation and Click-Chemistry for Vaccine Purposes

Published on: December 19, 2020

5.2K
Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation
10:58

Production of E. coli-expressed Self-Assembling Protein Nanoparticles for Vaccines Requiring Trimeric Epitope Presentation

Published on: August 21, 2019

7.8K

Area of Science:

  • Immunology and Virology
  • Carbohydrate Chemistry
  • Vaccine Development

Background:

  • The global HIV/AIDS pandemic necessitates an effective prophylactic vaccine.
  • Broadly neutralizing antibodies (bnAbs) have identified key epitopes on the HIV envelope (Env) spike.
  • Glycan-dependent epitopes on Env gp120 are targets for bnAb recognition.

Purpose of the Study:

  • To review progress in developing synthetic carbohydrate-based epitope mimics for HIV-1 vaccines.
  • To focus on eliciting bnAbs against specific Env gp120 regions: the outer domain high-mannose cluster and V1V2/V3 loops.
  • To discuss the design, synthesis, and evaluation of minimal immunogens for vaccine development.

Main Methods:

  • Design and synthesis of carbohydrate-based epitope mimics.
  • Biological evaluation of minimal immunogens.
  • Characterization of elicited broadly neutralizing antibodies (bnAbs).

Main Results:

  • Progress has been made in creating synthetic mimics of HIV-1 Env epitopes.
  • These mimics are designed to target specific regions recognized by bnAbs.
  • The study evaluates the immunogenicity and potential of these mimics.

Conclusions:

  • Synthetic carbohydrate-based epitope mimics show promise for HIV-1 vaccine development.
  • Targeting specific Env gp120 regions with minimal immunogens is a viable strategy.
  • Further development is key to achieving a successful protective HIV-1 vaccine.