An integrative toxicogenomic analysis of plastic additives

In developed countries, contact with plastics is constant. Plastics contain a vast number of additives such as plasticisers, stabilisers, antioxidants, flame retardants, etc., that can impact human health. Most of them have been studied separately; however, an integrative approach to identify genes, biological processes, molecular functions, and diseases linked to exposure to these compounds has not been addressed until now. The genes most commonly affected by plastic additives are related to apoptosis, cell death, proliferation and differentiation, immunity and insulin-related processes, and are mainly associated with cancer, mental disorders, diabetes mellitus type II and obesity. The most commonly affected molecular functions included steroid hormone receptor activity implicated in cancer, mental disorders, immune signalling and gonadotropin-releasing hormones. These processes and functions affected by plastic additives are related to the diseases of the developed world, most of which are linked to the endocrine system, such as cancer, diabetes, infertility and obesity. The strong interconnection among the top 50 genes modulated by plastic additives shows that the pathways affected are strongly interrelated. Therefore, studying the effects of plastic additives through a single-compound approach cannot be sufficient and a holistic approach is more appropriate for evaluating the potential effects of plastics in human health.