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Heteroclitic antibodies: differences in fine specificities between monoclonal antibodies directed against
1New York University Medical School, Department of Pathology, N.Y.
International Archives of Allergy and Applied Immunology
|January 1, 1988
Abstract:
The inhibition of binding of monoclonal antibodies by different haptens was studied using the 50% antibody binding assay. The binding of antidinitrophenyl and antitrinitrophenyl antibodies to dinitrophenylated or trinitrophenylated bovine serum albumin could be inhibited by monovalent dinitrophenyl or trinitrophenyl epsilon-aminocaproic acid. Some of the antibodies could be inhibited to a greater degree with the cross-reacting haptens than with the haptens homologous to the immunizing antigen, therefore these antibodies were heteroclitic.