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Optimization of Critical Quality Attributes in Tablet Film Coating and Design Space Determination Using Pilot-Scale

Huolong Liu1, Robert Meyer2, Matthew Flamm3

  • 1Department of Chemical Engineering, University of Massachusetts Lowell, 1 University Avenue, Lowell, Massachusetts, 01854, USA.

AAPS Pharmscitech
|January 3, 2021
PubMed
Summary

This study optimized high-speed tablet film coating in continuous manufacturing. Key variables were identified to ensure consistent tablet moisture and coating uniformity, facilitating quality by design.

Keywords:
Coating efficiencyCoating uniformityDesign of experiment (DoE)Design spacePharmaceutical manufacturingQuality by design (QbD)Tablet film coatingTablet moisture content

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