Unfolding Nrf2 in diabetes mellitus
Tapan Behl1, Ishnoor Kaur2, Aayush Sehgal2
1Chitkara College of Pharmacy, Chitkara University, Rajpura, Punjab, India. tapanbehl31@gmail.com.
Molecular Biology Reports
|January 3, 2021
Summary
The Nrf2 pathway shows promise in combating diabetes by reducing oxidative stress. Understanding this pathway offers new therapeutic strategies for diabetes mellitus.
Area of Science:
- Biochemistry
- Molecular Biology
- Endocrinology
Background:
- Diabetes mellitus remains a leading global cause of mortality and morbidity.
- Oxidative stress, induced by free radicals, is a key factor in diabetes development.
- The antioxidant response element (ARE)/Keap1/Nrf2 pathway is increasingly recognized for its role in cellular protection.
Purpose of the Study:
- To explore the role of the ARE/Keap1/Nrf2 pathway in the context of diabetes mellitus.
- To investigate the potential of Nrf2 pathway modulation for diabetes treatment.
Main Methods:
- Review of clinical trials and animal studies investigating the Nrf2 pathway.
- Analysis of the molecular mechanisms involving Nrf2 gene dissociation from Keap1 under stress.
- Examination of Nrf2's role in regulating metabolic and detoxifying enzymes.
Main Results:
- Nrf2 pathway activation demonstrates a promising effect in reversing diabetes.
- Nrf2 activation counteracts diabetes-induced oxidative stress.
- The Nrf2 gene plays a significant role in cellular interactions relevant to disease.
Conclusions:
- The ARE/Keap1/Nrf2 pathway is a critical molecular player in managing oxidative stress in diabetes.
- Targeting the Nrf2 pathway presents a potential therapeutic strategy for diabetes mellitus.
- Further research into Nrf2 regulation could yield novel treatments for metabolic disorders.
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