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Updated: Nov 23, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
A review on various aspects of organic synthesis using Comins' reagent
Duraipandi Devi Priya1, Chetan Lakshman1, Selvaraj Mohana Roopan2
1Chemistry of Heterocycles and Natural Product Research Laboratory, Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamilnadu, 632 014, India.
Abstract:
Recently, researchers have shown great interest in compounds such as triflate and enotriflate that are synthesized by Comins reagent. For the above-mentioned reason, we planned to review the works related to organic synthesis using Comins reagent. So this review includes a whole new investigation of the Comins reagent which is used for stereoselective conversion of α-keto ester, enolate to enol triflate of lactone and vinyl triflate to methyl ketone. Comins reagent plays an important role in regioselectivity such as transformations of ketone or dienolates into vinyl triflates and it has a major application in highly selective oxidation in an easy and environmentally friendly manner.
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