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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
Published on: February 14, 2017
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Platinoid effects on human plasmatic coagulation kinetics: a viscoelastic analysis.
1Department of Anesthesiology, The University of Arizona College of Medicine, 1501 North Campbell Avenue, P.O. Box 245114, Tucson, AZ, 85724-5114, USA. vgnielsen333@gmail.com.
Journal of Thrombosis and Thrombolysis
|January 3, 2021
Summary
Platinum and ruthenium compounds were tested for their effects on blood clotting. Ruthenium chloride significantly increased clotting by enhancing prothrombin activation, unlike platinum compounds.
Area of Science:
- Biochemistry
- Hematology
- Oncology
Background:
- Metals like cadmium, chromium, copper, and iron are known to affect blood coagulation.
- Platinum-based chemotherapy is associated with thromboembolic events, yet platinoids' effects on coagulation are unstudied.
Purpose of the Study:
- To investigate the impact of platinum (carboplatin, cisplatin) and ruthenium (ruthenium chloride, NAMI-A) compounds on human plasma coagulation.
- To determine if platinum and ruthenium compounds influence blood clotting parameters.
Main Methods:
- Human plasma was treated with equimolar concentrations of platinum and ruthenium compounds.
- Thrombelastography was used to assess changes in plasmatic coagulation.
- Specialized thrombelastography techniques were employed to investigate ruthenium chloride's effects.
Main Results:
- Platinum compounds (carboplatin, cisplatin) did not significantly alter coagulation.
- NAMI-A showed mild hypercoagulability, while ruthenium chloride induced marked hypercoagulability.
- Ruthenium chloride was found to enhance prothrombin activation, indicating procoagulant properties.
Conclusions:
- The hypercoagulability linked to platinum compounds in vivo may not stem from direct effects on plasma coagulation.
- Ruthenium compounds can promote blood clotting by enhancing the common coagulation pathway.
- Further research on ruthenium-based chemotherapeutics is recommended to evaluate their procoagulant activity and clinical safety.
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