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Related Concept Videos

Exercise and Cardiovascular Response01:20

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Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
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The cardiovascular system regulates the number of erythrocytes in the bloodstream to ensure optimal oxygen transport. It also prevents over-proliferation of these cells, which helps to maintain blood viscosity and flow rate.
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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Articles linked to this work by shared authors, journal, and citation graph.

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Correction to: Changes in Circulating Stem and Progenitor Cell Numbers Following Acute Exercise in Healthy Human Subjects: a Systematic Review and Meta-Analysis.

Stem cell reviews and reports·2021
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Related Experiment Video

Updated: Nov 23, 2025

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
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Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans

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Changes in Circulating Stem and Progenitor Cell Numbers Following Acute Exercise in Healthy Human Subjects: a

M Schmid1, J M Kröpfl1, C M Spengler2,3

  • 1Exercise Physiology Lab, Institute of Human Movement Sciences and Sport, ETH Zurich, Winterthurerstrasse 190, CH-8057, Zurich, Switzerland.

Stem Cell Reviews and Reports
|January 3, 2021
PubMed
Summary

Acute exercise mobilizes various stem and progenitor cells (SC), including endothelial (ESC), hematopoietic (HSC), and early/non-specified (enSC) types. The extent and timing of this SC mobilization differ across SC subpopulations, highlighting the need for standardized definitions.

Keywords:
Acute exerciseEndothelialHematopoieticKineticsMesenchymalMeta-analysisModerator variablesStem and progenitor cellsStem cell mobilizationSystematic review

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Last Updated: Nov 23, 2025

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Isolation of Endothelial Progenitor Cells from Healthy Volunteers and Their Migratory Potential Influenced by Serum Samples After Cardiac Surgery
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Area of Science:

  • Exercise physiology
  • Stem cell biology
  • Regenerative medicine

Background:

  • Acute exercise impacts circulating stem and progenitor cell (SC) numbers.
  • Subgroups like endothelial (ESC), hematopoietic (HSC), and mesenchymal (MSC) SCs are of particular interest.
  • A consensus on the mechanisms and extent of exercise-induced SC mobilization is lacking.

Purpose of the Study:

  • To systematically evaluate the effects of acute exercise on different SC subgroups in healthy humans.
  • To investigate factors influencing SC mobilization following exercise.
  • To synthesize current research on exercise and SCs.

Main Methods:

  • Systematic computerized search for trials measuring SC numbers before and after acute exercise.
  • Meta-analysis of identified studies.
  • Analysis of subject- and intervention-dependent factors.

Main Results:

  • Significant increases in early/non-specified SCs (enSCs) were observed up to 0.5 hours post-exercise.
  • Endothelial SCs (ESCs) showed increased numbers for up to 12-48 hours post-exercise.
  • Hematopoietic SCs (HSCs) were elevated at 0-5 minutes and 3 hours post-exercise.
  • Factors like sex, intensity, and duration generally did not influence mobilization.

Conclusions:

  • The extent and kinetics of exercise-induced SC mobilization vary among SC subpopulations.
  • Non-uniform definitions of SC subpopulations hinder consensus.
  • Standardized definitions for ESCs, HSCs, and MSCs are crucial for future research.