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Updated: Nov 23, 2025

Endoscopic Injection Sclerotherapy Assisted by Cyanoacrylate and Clips for Gastroesophageal Varices
Published on: June 13, 2025
Rectal varix treated with endoscopic cyanoacrylate injection therapy
Sotaro Ozaka1,2, Yasuhiko Gotoh3, Shunichiro Honda4
1Department of Gastroenterology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan. ozakaso@oita-u.ac.jp.
Endoscopic cyanoacrylate injection therapy successfully treated recurrent rectal varices in a cirrhosis patient. This approach offers a potentially safe and effective option for managing this challenging condition.
Area of Science:
- Gastroenterology
- Interventional Endoscopy
Background:
- Rectal varices, a complication of portal hypertension, lack established standardized treatments.
- Endoscopic cyanoacrylate injection is standard for gastric varices but less reported for rectal varices.
Observation:
- An 80-year-old male with cirrhosis presented with hematochezia and anemia due to recurrent rectal varices.
- Initial endoscopic cyanoacrylate injection was followed by bleeding, necessitating a second injection.
- The patient remained free of re-bleeding and recurrence at a 3-year follow-up.
Findings:
- Successful management of recurrent rectal varices was achieved using endoscopic cyanoacrylate injection therapy.
- The treatment required a secondary injection due to post-procedure bleeding.
Implications:
- Endoscopic cyanoacrylate injection therapy presents a viable and safe treatment alternative for rectal varices.
- Further research into this technique for rectal varices is warranted given its potential efficacy.
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