Related Experiment Video

Updated: Nov 23, 2025

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia
11:36

A Cell Culture Model for Studying the Role of Neuron-Glia Interactions in Ischemia

Published on: November 14, 2020

9.8K

Neurovascular Unit: A critical role in ischemic stroke

Liyun Wang1, Xiaoxing Xiong2, Luyuan Zhang3

  • 1Department of Neurosurgery, Shengzhou People's Hospital (the First Affiliated Hospital of Zhejiang University Shengzhou Branch), Shengzhou, China.

CNS Neuroscience & Therapeutics
|January 3, 2021
PubMed

Insights

Targeting the neurovascular unit (NVU) offers new hope for treating ischemic stroke (IS). Understanding the NVU

Area of Science:

  • Neuroscience
  • Cerebrovascular Medicine
  • Pathophysiology

Background:

  • Ischemic stroke (IS) is a major cause of death and disability worldwide.
  • Current IS treatments, primarily focused on recanalization, are often insufficient or inaccessible.
  • The neurovascular unit (NVU) plays a critical role in IS pathophysiology and recovery.

Purpose of the Study:

  • To review the relationship between NVU changes and IS outcomes.
  • To explore novel therapeutic strategies targeting the NVU for IS management.

Main Methods:

  • Literature review of studies on the neurovascular unit and ischemic stroke.
  • Analysis of the NVU's roles in blood-brain barrier regulation, cell protection, inflammation, and repair.
  • Summary of noncoding RNA influences and NVU-targeted therapies for IS.

Main Results:

  • The NVU is intricately linked to IS outcomes, including recanalization and prognosis.
  • NVU functions encompass blood-brain barrier integrity, cellular survival, immune responses, and repair mechanisms.
  • Noncoding RNAs significantly impact NVU function in the context of IS.

Conclusions:

  • The homeostatic state of the NVU is crucial for both IS pathophysiology and neurovascular repair.
  • Targeting the NVU presents a promising avenue for developing new and improved IS treatments.
  • Further research into NVU-based therapies could significantly expand treatment options for stroke patients.

Keywords:
IschemiaMicroRNAsNeurovascular unitStrokeTherapy

More Related Videos

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide09:52

Setting Up a Stroke Team Algorithm and Conducting Simulation-based Training in the Emergency Department - A Practical Guide

Published on: January 15, 2017

17.5K
Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model08:22

Isolation and Flow Cytometric Assessment of Neuroimmune Interactions in a Mini-Stroke Murine Model

Published on: June 20, 2025

279

Related Concept Videos

Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.3K
Regulation of Stroke Volume01:27

Regulation of Stroke Volume

The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
4.4K
Vascular Spasm01:16

Vascular Spasm

The vascular phase, also known as vasospasm, is the initial stage of hemostasis, crucial for preventing excessive bleeding when a blood vessel is injured. After a vessel is cut, nerves in the damaged area trigger pain and other sensory impulses. Simultaneously, the smooth muscles in the vessel wall contract, resulting in a vascular spasm. This contraction reduces the vessel's diameter at the injury site, slowing or stopping blood loss through the vessel wall. Vascular spasms typically last...
2.8K
Arteries of the Head and Neck01:26

Arteries of the Head and Neck

The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
2.3K
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
1.3K