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Primary intracranial leiomyosarcoma presenting with frontal bone mass: a case report
Shaghayegh Kamian1, Abdolali Ebrahimi2, Kaveh Ebrahim Zadeh3
1Department of Radiotherapy Oncology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Radiation Oncology Journal
|January 4, 2021
Summary
A rare primary intracranial leiomyosarcoma in a 31-year-old man was successfully treated with surgery, radiation, and chemotherapy. The patient remained disease-free for 34 months, showing effective treatment for this rare brain tumor.
Area of Science:
- Neuro-oncology
- Surgical Pathology
Background:
- Primary intracranial mesenchymal neoplasms are exceptionally rare.
- Most intracranial tumors of mesenchymal origin are metastases from other sites.
Observation:
- A 31-year-old male presented with a 6-month history of a growing frontal mass and headaches.
- No symptoms indicated metastatic disease elsewhere in the body.
Findings:
- Surgical resection achieved clear margins.
- Pathology and immunohistochemistry confirmed leiomyosarcoma grade II.
- The patient received adjuvant radiotherapy (60 Gy in 30 fractions) and four cycles of doxorubicin chemotherapy.
Implications:
- This case highlights a rare instance of primary intracranial leiomyosarcoma.
- Multimodal treatment (surgery, radiation, chemotherapy) can be effective in managing this aggressive tumor.
- Long-term disease-free survival is achievable with appropriate therapeutic strategies.
