Related Experiment Video
Updated: Nov 23, 2025
08:35
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
3.7K
Renal Denervation and Celiac Ganglionectomy Decrease Mean Arterial Pressure Similarly in Genetically Hypertensive
Ninitha Asirvatham-Jeyaraj1,2, Madeline M Gauthier3, Christopher T Banek1,3
1From the Department of Integrative Biology and Physiology, University of Minnesota, Minneapolis (M.M.G., C.T.B., A.R., J.W.O.).
Hypertension (Dallas, Tex. : 1979)
|January 4, 2021
Summary
Renal denervation and celiac ganglionectomy both reduce blood pressure in hypertensive mice. These procedures lower mean arterial pressure by reducing sympathetic tone, suggesting both renal and splanchnic nerves play a role in hypertension.
Area of Science:
- Cardiovascular Physiology
- Nephrology
- Surgical Innovation
Background:
- Resistant hypertension is a clinical challenge often managed with invasive procedures.
- Renal denervation (RDNX) is known to lower blood pressure, but the role of other autonomic pathways, like the splanchnic nerves, is less understood.
- The celiac ganglion innervates the splanchnic vascular bed, a key regulator of blood flow and pressure.
Purpose of the Study:
- To investigate the effects of RDNX and celiac ganglionectomy (CGX) on mean arterial pressure (MAP) in genetically hypertensive mice (BPH/2J).
- To determine if these procedures reduce sympathetic tone contributing to hypertension.
- To compare the efficacy of RDNX and CGX in lowering blood pressure and modulating neurogenic pressor activity.
Main Methods:
- Telemeters were implanted in BPH/2J mice to continuously monitor MAP.
- Mice underwent either RDNX, CGX, or a SHAM procedure.
- MAP, blood pressure, and heart rate were recorded for 14 days post-surgery. Global neurogenic pressor activity was assessed using hexamethonium, and tissue norepinephrine levels were measured to confirm denervation efficacy.
Main Results:
- Both RDNX and CGX significantly lowered MAP by approximately 11 mm Hg on postoperative day 14 compared to pre-procedure levels, while SHAM surgery showed a smaller reduction.
- The depressor response to hexamethonium was significantly blunted after RDNX, indicating reduced sympathetic tone.
- CGX also demonstrated a significant reduction in MAP, suggesting a role for the splanchnic nerves in maintaining hypertension in this model.
Conclusions:
- Both renal and splanchnic denervation effectively lower blood pressure in genetically hypertensive mice.
- These findings suggest that both renal and splanchnic neural pathways contribute to the pathogenesis of hypertension in BPH/2J mice.
- The mechanisms by which these interventions lower blood pressure may differ, warranting further investigation.
More Related Videos
07:25Assessing Murine Resistance Artery Function Using Pressure Myography
Published on: June 7, 2013
22.7K
11:08Novel Approach for Simultaneous Recording of Renal Sympathetic Nerve Activity and Blood Pressure with Intravenous Infusion in Conscious, Unrestrained Mice.
Published on: February 14, 2018
10.5K
Related Concept Videos
01:18Neural Regulation of Blood Pressure
6.1K
The neural regulation of blood pressure involves intricate interactions between the autonomic nervous system (ANS) and cardiovascular system, ensuring adequate perfusion of tissues. This regulation primarily occurs through baroreceptor and chemoreceptor reflexes, involving both short-term and long-term mechanisms.
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
6.1K
01:17Antihypertensive Drugs: Action of β1 Blockers
1.7K
β1-receptors are primarily located in the heart and kidneys. In cardiac myocytes, these receptors interact with neurotransmitters released by the sympathetic nervous system during heightened activity or danger. As a result, β1-receptors get activated, initiating a series of biochemical processes. Excessive activation of beta receptors due to chronic stress can abnormally increase heart rate and contractility, resulting in high blood pressure or hypertension. To counteract this,...
1.7K
01:26Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
673
The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
673
01:18Hypertension and Regulation of Blood Pressure
3.5K
Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
3.5K
01:30Antihypertensive Drugs: Angiotensin II Receptor Blockers
2.1K
In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
2.1K
01:28Drugs Acting on Autonomic Ganglia: Blockers
1.5K
Ganglionic blockers inhibit autonomic activity by blocking nicotinic receptors in the autonomic ganglia, suppressing impulse transmission. These blockers lack selectivity between sympathetic and parasympathetic ganglia and are ineffective as neuromuscular junction antagonists. They can be categorized into two groups:
1.5K