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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as A Novel Detection and Quantification Method
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Potential Non-coding RNAs from Microorganisms and their Therapeutic Use in the Treatment of Different Human Cancers

Raju Biswas1, Dipanjana Ghosh1, Bhramar Dutta1

  • 1UGC-Center of Advanced study, Department of Botany, The University of Burdwan, Golapbag, Burdwan-713104, West Bengal, India.

Current Gene Therapy
|January 4, 2021
PubMed

Insights

RNA interference (RNAi) offers a novel cancer therapy by silencing cancer genes with fewer side effects than traditional treatments. Further research into RNAi mechanisms and delivery systems promises improved cancer treatment strategies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biotechnology

Background:

  • Conventional cancer therapies include surgery, chemotherapy, and radiotherapy.
  • RNA interference (RNAi) is an emerging therapeutic strategy for targeting cancer-related genes.
  • RNAi-based therapies may offer a reduced side-effect profile compared to traditional treatments.

Purpose of the Study:

  • To review RNA interference (RNAi) as a novel cancer therapy.
  • To explore the potential of RNAi in silencing or targeting cancer-related genes.
  • To discuss RNAi-based drug delivery approaches for cancer treatment.

Main Methods:

  • Analysis of transcription signal sequences and conserved sequences.
  • Review of existing literature on RNA interference mechanisms in cancer.
  • Exploration of RNAi-based drug delivery systems.

Main Results:

  • Microorganisms identified as a potential source of non-coding RNAs for RNAi.
  • RNAi demonstrates antiproliferative and proapoptotic effects by targeting oncogenic molecules.
  • RNAi mechanisms can effectively knock down cancer-related gene products.

Conclusions:

  • RNA interference presents a promising alternative cancer therapy with potentially fewer side effects.
  • Understanding RNAi mechanisms and optimizing drug delivery are crucial for its clinical application.
  • Further development in RNAi technology is expected to enhance future cancer treatment prospects.
Keywords:
Cancer therapyRNA interferenceRNAi based therapycarcinogenicdrugs deliverymicroorganisms

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