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[Safe Handling Method for Splitting Azathioprine Tablets].

Manahito Aoki1,2, Satsuki Oda1, Satoshi Kubota2

  • 1Department of Clinical Pharmacy, Research and Education Center for Clinical Pharmacy, School of Pharmacy, Kitasato University.

Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|January 4, 2021
PubMed
Summary

To minimize hazardous drug exposure, wear gloves when splitting azathioprine (AZA) tablets. Change gloves before packaging and implement thorough cleaning protocols for AZA dispensing tools and surfaces.

Keywords:
azathioprinecleaninghazardous drugoccupational exposuresafe handlingtablet splitting

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Area of Science:

  • Pharmaceutical Sciences
  • Occupational Health and Safety
  • Drug Handling and Compounding

Background:

  • Azathioprine (AZA) is an immunosuppressant classified as a hazardous drug.
  • Tablet splitting can increase AZA exposure risk due to contamination.
  • Limited research exists on AZA contamination during splitting and dispensing.

Purpose of the Study:

  • To investigate and quantify azathioprine (AZA) contamination and exposure risks during tablet splitting and dispensing.
  • To compare different dispensing methods based on the use of tweezers.
  • To establish safe handling protocols for AZA.

Main Methods:

  • Three dispensing methods were evaluated, differing in the use of tweezers during splitting and packaging.
  • Azathioprine (AZA) contamination was quantified by wiping tools, packaging machines, and counters after splitting and dispensing.
  • Three consecutive wipes with water-dampened cloths were used for quantification.

Main Results:

  • Significant AZA adhered to gloves in methods without tweezers during tablet handling (Methods 1 and 2).
  • Using tweezers for tablet handling (Method 3) reduced glove contamination.
  • Third-round wipe tests showed no detectable AZA at most sites, indicating effective cleaning.

Conclusions:

  • Gloves are essential during AZA tablet splitting.
  • Changing gloves before packaging is crucial to prevent cross-contamination.
  • Double or triple wiping of equipment and surfaces with a damp cloth effectively removes residual AZA.