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Four New Pregnane-10,2-carbolactones from an Epipolasis sp. Marine Sponge
Unwoo Kang1, Dongdong Wang1, Heidi R Bokesch1,2
1Molecular Targets Program, Center for Cancer Research, National Cancer Institute.
Abstract:
Four new pregnane steroids, 3β,4β,16β-trihydroxypregna-5,17-diene-10,2-carbolactone (1), 16β-acetoxy-3β,4β-dihydroxypregna-5,17-diene-10,2-carbolactone (2), 12β-acetoxy-3β,4β,16β-trihydroxypregna-5,17-diene-10,2-carbolactone (3), and 12β,16β-diacetoxy-3β,4β-dihydroxypregna-5,17-diene-10,2-carbolactone (4) were isolated from an extract of an Epipolasis sp. marine sponge. The structures of the new compounds were determined by extensive NMR spectroscopic analysis and comparison with data from previously reported compounds.
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