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COVID-19 in patients living with human immunodeficiency virus (HIV) infection: Challenges and way-forward

Manasvini Bhatt1, Manish Soneja1, Nitin Gupta2

  • 1Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Drug Discoveries & Therapeutics
|January 4, 2021
PubMed

Insights

Patients with human immunodeficiency virus (HIV) often experience worse outcomes from coronavirus disease 2019 (COVID-19). This is due to factors like lymphopenia, comorbidities, and reduced access to routine care.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Public Health

Background:

  • Coronavirus disease 2019 (COVID-19) poses significant risks to global health.
  • Human immunodeficiency virus (HIV) infection is a chronic condition affecting millions worldwide.
  • Co-infection with COVID-19 and HIV presents unique clinical challenges.

Purpose of the Study:

  • To review the current understanding of COVID-19's impact on individuals with HIV.
  • To identify factors contributing to worse COVID-19 outcomes in the HIV population.
  • To highlight the challenges in managing HIV care during the COVID-19 pandemic.

Main Methods:

  • Literature review of existing studies on COVID-19 in HIV patients.
  • Analysis of factors contributing to disease severity.
  • Discussion of healthcare resource allocation challenges.

Main Results:

  • Studies consistently report poorer outcomes for COVID-19 patients with HIV.
  • Lymphopenia, higher comorbidity rates, and pre-existing lung damage are key contributing factors.
  • Disruption of routine HIV care due to resource diversion exacerbates the problem.

Conclusions:

  • COVID-19 disproportionately affects individuals living with HIV, leading to worse clinical outcomes.
  • Addressing the unique vulnerabilities of HIV patients is crucial for effective pandemic response.
  • Maintaining access to consistent HIV care is essential during public health crises.

Keywords:
COVID-19HIVtuberculosis

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