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miR-340: A multifunctional role in human malignant diseases.
Zheng Huang1,2, Yesha Xu1, Maoping Wan1
1Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou 325035, Zhejiang, P.R. China.
International Journal of Biological Sciences
|January 4, 2021
Summary
MicroRNAs (miRNAs) are key regulators in cancer. This review clarifies the complex roles of miR-340 in human malignancies, exploring its potential in cancer diagnosis, treatment, and prognosis.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNAs (miRNAs) are short non-coding RNAs regulating gene expression.
- Dysregulated miRNAs are implicated in various diseases, including multiple cancers.
- miR-340's dual role as an oncogene or tumor suppressor is emerging.
Purpose of the Study:
- To review the critical roles of miR-340 in human cancers.
- To clarify miR-340's function in cancer diagnosis, treatment, and prognosis.
- To propose future research directions for miR-340 in oncology.
Main Methods:
- Literature review of recent research studies on miR-340 in human cancers.
- Analysis of miR-340's targeting of genes involved in proliferation, apoptosis, and metastasis.
- Examination of miR-340's involvement in signaling pathways like Wnt/β-catenin and JAK-STAT.
Main Results:
- miR-340 exhibits context-dependent functions in various cancers.
- It targets genes crucial for cancer cell proliferation, apoptosis, and metastasis.
- miR-340 is implicated in cancer diagnosis, treatment response, and patient prognosis.
Conclusions:
- miR-340 plays a significant, yet complex, role in human malignancies.
- Understanding miR-340 mechanisms is vital for improving cancer therapeutics.
- Further investigation is warranted to fully elucidate miR-340's clinical utility.
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