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Updated: Nov 23, 2025

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
07:41

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

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Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis

Lixia Lu1,2,3, Jianglin Zhang1,2,3, Pingping Gan4

  • 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, Hunan China.

International Journal of Biological Sciences
|January 4, 2021
PubMed

Insights

Mitochondrial CD147 promotes melanoma invasion and metastasis by interacting with HSP60 to activate ATP5B, leading to worse patient prognosis. This finding identifies CD147 as a potential therapeutic target for aggressive skin cancer.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cell Biology

Background:

  • Melanoma is an aggressive skin cancer known for rapid invasion and metastasis.
  • CD147 is implicated in cellular invasion processes.

Purpose of the Study:

  • To investigate the role of CD147 translocation to mitochondria in advanced melanoma.
  • To explore the relationship between mitochondrial CD147 and melanoma invasion, metabolism, and patient prognosis.

Main Methods:

  • Analysis of CD147 localization in melanoma cells and patient tissues.
  • Assessment of mitochondrial CD147 levels in relation to invasion potential and energy metabolism.
  • Protein-protein interaction studies (STRING, Co-IP) involving CD147, HSP60, and ATP5B.
  • Correlation analysis and survival curve generation for patient data.

Main Results:

  • CD147 translocates to mitochondria in advanced melanoma, correlating with worse prognosis.
  • Mitochondrial CD147 levels are linked to melanoma cell invasion and mitochondrial energy metabolism.
  • CD147 depletion reduces mitochondrial complex V activity; CD147 interacts with HSP60 and ATP5B.
  • HSP60 upregulation also correlates with poorer melanoma patient outcomes.

Conclusions:

  • Mitochondrial CD147 promotes melanoma invasion by potentially activating ATP5B via HSP60, enhancing aerobic oxidation and invasive capabilities.
  • CD147's mitochondrial localization serves as a prognostic marker for melanoma patients.
  • CD147 represents a promising therapeutic target for combating melanoma invasion and metastasis.
Keywords:
CD147MelanomaMitochondriaaerobic oxidationinvasion

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