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Updated: Nov 23, 2025
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
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CircRNA ciRS-7: a Novel Oncogene in Multiple Cancers
Junwen Chen1, Jun Yang2, Xiang Fei1
1Department of Urology, Shengjing Hospital of China Medical University, Shenyang 110004, China.
International Journal of Biological Sciences
|January 4, 2021
Summary
Circular RNA ciRS-7 (ciRS-7) acts as an oncogene by sponging miR-7, promoting tumor progression. This review details ciRS-7
Area of Science:
- Molecular Biology
- Oncology
- Genetics
Background:
- Circular RNA ciRS-7 (ciRS-7) is an endogenous RNA molecule with a unique closed structure.
- First identified as a microRNA sponge in 2013, ciRS-7 has garnered significant research interest.
- It plays a key role in regulating gene expression, including RNA transcription and protein production.
Purpose of the Study:
- To review the biological characteristics and molecular mechanisms of ciRS-7.
- To explore the role of ciRS-7 as an oncogene in various cancers.
- To discuss future challenges and research directions for ciRS-7 in oncology.
Main Methods:
- Literature review of studies on ciRS-7 and its role in cancer.
- Analysis of molecular mechanisms involving ciRS-7 and microRNA-7 (miR-7) interactions.
- Compilation of data on ciRS-7 association with different cancer types.
Main Results:
- ciRS-7 functions as an oncogene by competitively inhibiting miR-7.
- This inhibition promotes tumor progression across numerous cancer types.
- Associated cancers include breast, lung, liver, colorectal, and pancreatic cancers, among others.
Conclusions:
- ciRS-7 is a significant oncogenic circRNA implicated in diverse malignancies.
- Understanding its mechanisms is crucial for developing targeted cancer therapies.
- Further research is needed to address the challenges and therapeutic potential of ciRS-7.
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