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Related Experiment Video

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Dickkopf-3: Current Knowledge in Kidney Diseases.

Xiangdong Fang1, Jing Hu2, Yanxia Chen1

  • 1Department of Nephrology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.

Frontiers in Physiology
|January 4, 2021
PubMed
Summary
This summary is machine-generated.

Urinary Dickkopf-related protein 3 (DKK3) shows promise as a biomarker for kidney diseases like chronic kidney disease (CKD) and acute kidney injury. Its role varies, but monitoring DKK3 levels could aid in diagnosis and treatment assessment.

Keywords:
Dickkopf-related protein 3biomarkerchronic kidney diseaseidiopathic membranous nephropathywnt signaling pathway

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Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Molecular Pathology

Background:

  • Dickkopf-related protein 3 (DKK3) is a secreted glycoprotein involved in various disease processes.
  • Emerging evidence points to DKK3's potential as a urinary biomarker for kidney disease.
  • Understanding DKK3's differential roles in kidney conditions is crucial for clinical application.

Purpose of the Study:

  • To review the biological functions of DKK3 in different kidney diseases.
  • To explore the clinical utility of urinary DKK3 as a diagnostic and monitoring tool.
  • To highlight DKK3's potential in assessing disease progression and treatment efficacy.

Main Methods:

  • Literature review of studies investigating Dickkopf-related protein 3 (DKK3) in kidney diseases.
  • Analysis of DKK3's role as an agonist or antagonist in specific renal pathologies.
  • Evaluation of current and potential clinical applications of urinary DKK3 measurements.

Main Results:

  • DKK3 acts as an agonist in chronic kidney disease (CKD) and autosomal dominant polycystic kidney disease (ADPKD).
  • DKK3 functions as an antagonist in idiopathic membranous nephropathy (IMN).
  • Urinary DKK3 shows potential as a biomarker for acute kidney disease and CKD, including tubulointerstitial fibrosis.

Conclusions:

  • Urinary DKK3 is a promising biomarker for monitoring kidney disease progression and treatment response.
  • Further research on DKK3's mechanisms and diagnostic utility is warranted.
  • DKK3 may improve early detection and understanding of kidney disease pathology.