Related Experiment Video
Updated: Nov 23, 2025
11:15
A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells
Published on: May 6, 2018
10.5K
Tumor-Derived Extracellular Vesicles and the Immune System-Lessons From Immune-Competent Mouse-Tumor Models
Marvin Droste1,2, Basant K Thakur3, Brian P Eliceiri1
1Department of Surgery, Division of Trauma, Surgical Critical Care and Burns, UC San Diego School of Medicine, San Diego, CA, United States.
Frontiers in Immunology
|January 4, 2021
Summary
Tumor-derived extracellular vesicles (TEVs) in animal models reveal their complex immune roles in cancer. Understanding TEVs in vivo is crucial for developing novel cancer immunotherapies and vaccines.
Area of Science:
- Immunology
- Oncology
- Extracellular Vesicles Research
Background:
- Tumor-derived extracellular vesicles (TEVs) significantly influence cancer immune responses.
- Most current research relies on cell culture, limiting in vivo validation.
- Immune-competent murine models offer a robust platform for studying TEVs in vivo.
Purpose of the Study:
- To review the role of TEVs in mediating crosstalk between tumor cells and immune cells using in vivo animal models.
- To clarify the heterogeneous effects of TEVs on anti-tumor immunity and immune evasion.
- To explore the therapeutic potential of TEVs in cancer vaccines and immunotherapies.
Main Methods:
- Review of current literature on TEVs in in vivo tumor-bearing animal models.
- Focus on studies examining TEV interactions with adaptive and innate immune cells.
- Analysis of findings from TEV-based cancer vaccine and immunotherapy trials.
Main Results:
- TEVs play a critical role in intercellular communication within the tumor microenvironment.
- Animal models help elucidate the dual role of TEVs in promoting or suppressing anti-tumor immunity.
- TEVs demonstrate potential for direct antigen presentation, supporting their use in cancer vaccines.
Conclusions:
- In vivo animal models are essential for understanding TEV functions and heterogeneity in cancer.
- TEVs hold significant promise as a novel platform for cancer immunotherapy and vaccine development.
- Further research and methodological advancements are needed to translate TEV-based therapies to human trials.
Related Concept Videos
02:43Mouse Models of Cancer Study
6.1K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.1K
02:17The Tumor Microenvironment
7.3K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
7.3K
01:27Tumor Immunotherapy
877
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
877