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GINS2 attenuates the development of lung cancer by inhibiting the STAT signaling pathway

Dianmin Sun1,2, Yuanyuan Zong3,2, Jinling Cheng4

  • 1Department of Thoracic Surgery, Shandong Cancer Hospital Affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China.

Journal of Cancer
|January 4, 2021
PubMed

Insights

GINS2 (GINS complex subunit 2) promotes lung cancer cell proliferation. Inhibiting GINS2 suppressed tumor growth and affected the STAT signaling pathway, suggesting GINS2 as a potential lung cancer biomarker.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • GINS complex subunit 2 (GINS2) is implicated in DNA replication and upregulated in aggressive tumors.
  • The role of GINS2 in lung cancer pathogenesis and progression is not well understood.

Purpose of the Study:

  • To investigate the clinical significance and functional role of GINS2 in lung cancer.
  • To elucidate the underlying molecular mechanisms of GINS2 action in lung cancer.

Main Methods:

  • TCGA database analysis for GINS2 expression in lung cancer tissues.
  • In vitro studies using A549 cells with GINS2 knockdown (MTT, flow cytometry, colony formation, cell cycle analysis, RNA sequencing).
  • In vivo studies assessing tumor growth and burden in nude mice.

Main Results:

  • GINS2 mRNA and protein were highly expressed in lung cancer tissues.
  • GINS2 knockdown inhibited lung cancer cell proliferation, colony formation, and induced cell cycle arrest and apoptosis.
  • Tumor growth and burden were significantly reduced in mice with GINS2 knockdown.
  • GINS2 knockdown led to upregulation of STAT1 and STAT2 expression.

Conclusions:

  • GINS2 promotes lung cancer cell proliferation, potentially by inhibiting the STAT signaling pathway.
  • GINS2 may serve as a potential diagnostic or prognostic biomarker for lung cancer.
Keywords:
GINS2STATapoptosislung cancerproliferation

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