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Acyclovir for recurrent erythema multiforme caused by herpes simplex.

¹Department of Dermatology, University of Colorado Health Sciences Center, Denver 80262.

Journal of the American Academy of Dermatology

|January 1, 1988

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Continuous suppressive oral acyclovir effectively controls herpes-associated erythema multiforme. However, acyclovir is ineffective once herpes simplex recurrence is evident or erythema multiforme has already occurred.

Area of Science:

Dermatology
Virology
Immunology

Background:

Herpes-associated erythema multiforme (HAEM) is a significant clinical concern.
Recurrent herpes simplex virus (HSV) infections are known triggers for HAEM.
Current treatment strategies for HAEM are limited.

Purpose of the Study:

To evaluate the efficacy of oral acyclovir in controlling HAEM.
To determine the optimal timing for acyclovir administration in preventing HAEM.
To explore the role of topical acyclovir in HAEM prevention.

Main Methods:

Retrospective analysis of patient data.
Review of treatment protocols for oral and topical acyclovir.
Correlation of HSV recurrence timing with HAEM onset.

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Main Results:

Continuous suppressive oral acyclovir treatment effectively controls HAEM.
Acyclovir administered after evident HSV recurrence or after HAEM onset is ineffective.
The efficacy of continuous topical acyclovir for HAEM prevention requires further investigation.
HAEM can be triggered by HSV recurrences at various body sites.

Conclusions:

Prophylactic continuous oral acyclovir is crucial for managing HAEM.
Timely intervention with acyclovir before HSV recurrence is key.
Further research is needed to confirm the role of topical acyclovir in HAEM prevention.