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Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

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Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
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Tumor Immunotherapy01:27

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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Targeted Cancer Therapies02:57

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
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Related Experiment Video

Updated: Nov 23, 2025

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
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Tumor Microenvironment-Stimuli Responsive Nanoparticles for Anticancer Therapy.

Reju George Thomas1,2, Suchithra Poilil Surendran1,2, Yong Yeon Jeong1,2

  • 1Department of Radiology, Chonnam National University Hwasun Hospital, Hwasun, South Korea.

Frontiers in Molecular Biosciences
|January 4, 2021
PubMed
Summary

Stimuli-responsive nanoparticle drug delivery systems enhance cancer treatment by encapsulating drugs and targeting tumors. These systems offer controlled release based on the tumor microenvironment, improving therapeutic efficiency.

Keywords:
cancerdrug releasenanoparticlestimulitumor microenvironment

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Area of Science:

  • Oncology
  • Nanotechnology
  • Drug Delivery

Background:

  • Cancer impacts a significant global population, necessitating advanced therapeutic strategies.
  • Conventional chemotherapy faces challenges with drug solubility, circulation time, and targeted delivery.
  • Nanotechnology offers innovative solutions for improved cancer treatment efficacy.

Purpose of the Study:

  • To review internal stimuli-responsive nanoparticle drug delivery systems for cancer therapy.
  • To summarize systems responding to internal cancer microenvironment cues.
  • To provide future perspectives on stimuli-responsive nanomedicine.

Main Methods:

  • Literature review of stimuli-responsive nanoparticle drug delivery systems.
  • Focus on internal stimuli: pH, redox, enzyme, reactive oxygen species (ROS), and hypoxia.
  • Analysis of system characteristics and drug release control mechanisms.

Main Results:

  • Nanoparticle systems effectively encapsulate insoluble chemotherapeutic agents.
  • These systems prolong drug circulation time and enable site-specific delivery.
  • Stimuli-responsive systems offer enhanced control over drug release within the tumor.

Conclusions:

  • Stimuli-responsive nanoparticle drug delivery systems represent a promising advancement in cancer therapy.
  • Tailoring release mechanisms to the tumor microenvironment can significantly boost treatment outcomes.
  • Further research into these advanced nanocarriers holds potential for future cancer treatment innovations.