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Idiopathic adulthood ductopenia with elevated transaminase only: A case report
Xiao-Chen Zhang1, Di Wang1, Xiang Li1
1Department of Hepatology, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China.
World Journal of Clinical Cases
|January 4, 2021
Summary
Idiopathic adulthood ductopenia (IAD) can present early as elevated transaminases without jaundice. Ursodeoxycholic acid treatment showed a significant response in a case of IAD.
Area of Science:
- Hepatology
- Gastroenterology
- Internal Medicine
Background:
- Idiopathic adulthood ductopenia (IAD) is a chronic cholestatic liver disease of unknown cause.
- It is characterized by adult onset, lack of autoantibodies, and loss of interlobular bile ducts.
Observation:
- A 27-year-old woman presented with elevated transaminases and alkaline phosphatase without jaundice.
- Previous abnormal transaminases were noted five years prior, but without cholestasis.
- Despite hepatoprotective drugs, transaminases remained elevated, prompting hospital admission.
Findings:
- Liver biopsy confirmed the diagnosis of Idiopathic adulthood ductopenia (IAD).
- Treatment with ursodeoxycholic acid for two weeks resulted in significant serological and histological improvement.
- IAD can manifest as elevated transaminases in its early stages, preceding cholestasis.
Implications:
- Early detection of IAD may be possible through monitoring transaminase levels.
- Ursodeoxycholic acid is an effective treatment for Idiopathic adulthood ductopenia.
- This case highlights the varied presentations of IAD, emphasizing the need for thorough diagnosis.
