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Coagulopathy in elderly patients with coronavirus disease 2019

Xueting Yuan1, Xunliang Tong2, Yan Wang2

  • 1The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences P. R. China.

Aging Medicine (Milton (N.S.W))
|January 4, 2021
PubMed

Insights

Elderly patients with COVID-19 show a higher prevalence of hypercoagulable states, indicated by elevated D-dimer and fibrinogen levels. This coagulopathy is linked to increased systemic inflammation in older individuals.

Area of Science:

  • Medical Research
  • Hematology
  • Infectious Diseases

Background:

  • Clinical features of COVID-19 have been extensively studied.
  • Coagulopathy in elderly COVID-19 patients remains underreported.

Purpose of the Study:

  • To investigate coagulopathy in elderly COVID-19 patients.
  • To compare coagulation parameters between elderly and younger COVID-19 patients.

Main Methods:

  • Retrospective analysis of coagulation parameters in 189 COVID-19 patients.
  • Patients categorized into older (≥65 years) and younger (<65 years) groups.

Main Results:

  • Elderly patients exhibited significantly higher D-dimer and fibrinogen levels.
  • Older COVID-19 patients showed a higher proportion of elevated fibrinogen and D-dimer.
  • Coagulation parameters correlated positively with inflammatory markers like CRP and IL-6.

Conclusions:

  • Elderly COVID-19 patients are more prone to hypercoagulable states.
  • Coagulopathy in these patients is associated with excessive systemic inflammation.
Abstract

Keywords:
COVID‐19agedblood coagulation disordersinflammation

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