Related Experiment Video
Updated: Nov 23, 2025

Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
Sustaining efficient immune functions with regular physical exercise in the COVID-19 era and beyond
Guilherme Eustáquio Furtado1,2,3, Rubens Vinícius Letieri4,5, Adriana Caldo-Silva3
1Health Sciences Research Unit, Nursing (UICISA:E), Nursing School of Coimbra (ESEnfC), Coimbra, Portugal.
Regular physical activity boosts immune function, crucial for combating COVID-19 (coronavirus disease). This review explores how exercise can enhance immunity during and after the pandemic.
Area of Science:
- Immunology
- Public Health
- Exercise Science
Background:
- The COVID-19 pandemic necessitated public health measures, including social isolation, which disrupted regular physical activity.
- Physical activity is vital for overall health, supporting cardiovascular, respiratory, osteo-muscular, and immune system functions.
- Sedentary behavior due to COVID-19 restrictions negatively impacts health and immune capacity.
Purpose of the Study:
- To review the impact of COVID-19 on active lifestyles.
- To discuss the potential benefits of exercise-induced immune enhancement against COVID-19 severity.
- To explore how exercise adherence can improve immune responses in the COVID-19 era and beyond.
Main Methods:
- This is a narrative review based on existing scientific literature.
- The review synthesizes current research on physical activity, immunity, and COVID-19.
- It discusses the implications of exercise for immune function in the context of the pandemic.
Main Results:
- Physical inactivity linked to COVID-19 public health measures has detrimental effects on health.
- Regular exercise can bolster immune system responses.
- Enhanced immunity through exercise may mitigate COVID-19 severity or progression.
Conclusions:
- Maintaining physical activity is essential for immune health during the COVID-19 pandemic.
- Exercise can be a valuable strategy to improve immune resilience against viral infections like COVID-19.
- The findings support the integration of exercise into public health strategies for pandemic preparedness and recovery.
More Related Videos
Related Concept Videos
Immunological Memory
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Development of Immunocompetence
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
Functions of the Lymphatic and Immune System
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be...
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...

