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Updated: Nov 23, 2025

Oral Combinational Antiretroviral Treatment in HIV-1 Infected Humanized Mice
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Weight-adapted fixed-dose combined adult antiretroviral tablets for HIV-infected children

Ferran Bossacoma Busquets1, Emilia Sánchez2, Antoni Noguera-Julián3

  • 1Fundació Sant Joan de Déu, Fundacio Salut Emporda, Pharmacy, Barcelona, Spain.

Journal of Clinical Pharmacy and Therapeutics
|January 4, 2021
PubMed

Insights

Individualized dose compounded capsules (IDCC) of abacavir/lamivudine (ABC/3TC) offer a safe and effective way to manage HIV in children. This simplified antiretroviral therapy (ART) approach maintained viral suppression without adverse events.

Area of Science:

  • Pediatric infectious diseases
  • Pharmacology and therapeutics
  • HIV/AIDS management

Background:

  • Antiretroviral therapy (ART) simplification is crucial for HIV-infected children.
  • Existing fixed-dose combinations may not be suitable for all pediatric weight classes.
  • Abacavir/lamivudine (ABC/3TC) individualized dose compounded capsules (IDCC) offer a potential solution.

Purpose of the Study:

  • To evaluate the feasibility, safety, and efficacy of ABC/3TC IDCC in HIV-infected children.
  • To assess the long-term outcomes of this individualized ART regimen.

Main Methods:

  • Prospective case series of 13 HIV-infected children treated with weight-adapted ABC/3TC IDCC.
  • Monitoring of CD4 cell counts, weight, and height z-scores.
  • Assessment of viral replication and adherence to ART.

Main Results:

  • Treatment with ABC/3TC IDCC was feasible for a median of 30 months.
  • No significant changes in CD4 counts or growth parameters were observed.
  • Viral suppression was achieved or maintained in 12 out of 13 patients, with no reported adverse events.

Conclusions:

  • Long-term use of ABC/3TC IDCC is a safe, feasible, and effective strategy for treating HIV-infected children.
  • This individualized approach supports sustained viral suppression in pediatric populations.
  • ABC/3TC IDCC represents a valuable therapeutic alternative for children unable to use standard fixed-dose combinations.
Abstract

Keywords:
abacaviradherenceantiretroviralchildrenfixed-dose combinationslamivudine

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