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Risk factors for mortality of 557 adult patients with COVID 19 in Babol, Northern Iran: a retrospective cohort study

M Javanian, M Bayani, M Shokri

    Bratislavske Lekarske Listy
    |January 4, 2021
    PubMed

    Insights

    Older age, cerebrovascular diseases, and complications like septic shock and acute respiratory distress syndrome (ARDS) significantly increase COVID-19 mortality risk. Understanding these factors is crucial for patient outcomes.

    Area of Science:

    • Epidemiology
    • Critical Care Medicine
    • Infectious Diseases

    Background:

    • COVID-19 poses a significant global health threat.
    • Identifying mortality risk factors is essential for effective patient management.
    • Previous studies have explored various risk factors, but regional data is crucial.

    Purpose of the Study:

    • To investigate the key risk factors associated with mortality in COVID-19 patients.
    • To provide data from Babol, Northern Iran, to inform local and broader public health strategies.
    • To analyze the impact of comorbidities and complications on COVID-19 outcomes.

    Main Methods:

    • Retrospective cohort study design.
    • Inclusion of 121 deceased and 436 discharged COVID-19 cases.
    • Data collected from March 1 to April 1, 2020, in Babol, Northern Iran.

    Main Results:

    • Older age, cerebrovascular disease, ICU admission, and ventilator-associated pneumonia (VAP) were significant risk factors for mortality.
    • Complications including septic shock, acute respiratory distress syndrome (ARDS), acute kidney failure (AKF), and acute heart failure (AHF) substantially increased mortality risk.
    • Lower lymphocyte count was also strongly associated with increased mortality.

    Conclusions:

    • Elderly patients with comorbidities like cerebrovascular diseases face a higher risk of death from COVID-19.
    • Severe complications such as pneumonia, septic shock, ARDS, AHF, and AKF are critical determinants of mortality.
    • These findings underscore the importance of managing comorbidities and preventing complications in COVID-19 patients.
    Abstract

    Keywords:
    COVID-19clinical characteristics laboratory findings.mortality

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