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Neurological symptoms in COVID-19 patients
Bratislavske Lekarske Listy
|January 4, 2021
Summary
COVID-19 patients frequently experience neurological symptoms, including headache and muscle injury, regardless of disease severity. These findings suggest the nervous and muscle systems may be viral targets, with potential implications for predicting disease progression.
Area of Science:
- Neurology
- Infectious Diseases
- Virology
Background:
- Coronaviruses (CoVs), including SARS-CoV-2, exhibit neurotropism.
- SARS-CoV-2 utilizes angiotensin-converting enzyme 2 (ACE2) receptors, present in the brain and skeletal muscles.
- Limited knowledge exists regarding neurological manifestations in COVID-19 patients.
Purpose of the Study:
- To investigate the prevalence of neurological symptoms in hospitalized COVID-19 patients.
- To contribute to the understanding of neurotropism in SARS-CoV-2 infections.
- To explore potential correlations between neurological symptoms, muscle injury, and disease severity.
Main Methods:
- A cohort of 51 hospitalized COVID-19 patients was analyzed.
- Patients were diagnosed based on WHO interim guidelines.
- Participants were categorized into mild and severe disease subgroups.
Main Results:
- Neurological symptoms were observed in 31.37% of patients, with headache being the most common (17.65%).
- Muscle injury was detected in 19.61% of patients.
- No significant differences in the frequency of neurological symptoms or muscle involvement were found between mild and severe disease groups.
Conclusions:
- The nervous and skeletal muscle systems are potential targets for SARS-CoV-2.
- Certain neurological findings may aid in predicting disease course.
- Laboratory values could potentially predict disease severity and neurological symptoms.
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