Related Experiment Video
Updated: Nov 23, 2025
07:50
Genome-Wide Analysis of DNA Methylation in Gastrointestinal Cancer
Published on: September 18, 2020
5.9K
XPG gene polymorphisms and glioma susceptibility: a two-centre case-control study
1Department of Pathology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, China.
British Journal of Biomedical Science
|January 4, 2021
Summary
Certain Xeroderma pigmentosum group G (XPG) gene variants increase the risk of childhood glioma. These XPG variants may aid in the early diagnosis of pediatric glioma.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Glioma is a common pediatric cancer with poor outcomes.
- Xeroderma pigmentosum group G (XPG) is involved in DNA repair and cancer susceptibility.
- The role of XPG variants in pediatric glioma risk is not well understood.
Purpose of the Study:
- To investigate the association between XPG gene polymorphisms and the risk of glioma in children.
- To identify specific XPG variants that may contribute to pediatric glioma development.
Main Methods:
- Genotyping of five XPG polymorphisms (rs2094258, rs751402, rs2296147, rs1047768, rs873601) in 171 pediatric glioma cases and 228 controls.
- Statistical analysis to determine the association between XPG variants and glioma risk.
- Expression quantitative trait locus (eQTL) analysis for functional exploration.
Main Results:
- The XPG polymorphism rs2094258 C>T was associated with decreased glioma risk.
- XPG polymorphisms rs1047768 C and rs873601 A alleles were linked to increased glioma risk.
- Carrying five specific XPG risk genotypes significantly elevated glioma risk (OR=1.97), particularly in males, older children (>60 months), and those with astrocytic tumors.
Conclusions:
- Specific variants in the XPG gene are identified as risk factors for pediatric glioma.
- These XPG variants may serve as potential biomarkers for early diagnosis and risk assessment in children.
- Further research into XPG's role in DNA repair could inform glioma treatment strategies.
More Related Videos
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
14.9K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.9K
01:05Single Nucleotide Polymorphisms-SNPs
17.4K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.4K