Related Experiment Video
Updated: Nov 23, 2025
07:08
Modeling and Imaging 3-Dimensional Collective Cell Invasion
Published on: December 7, 2011
17.1K
Invasion and metastasis: a historical perspective.
Carlo Patriarca1, Giacomo Maria Pini2, Giario Conti3
1Pathology Unit Ospedale St Anna, ASST Lariana, Como, Italy.
Pathologica
|January 4, 2021
Summary
Neoplasm progression was historically viewed as linear, leading to aggressive surgical approaches. Modern understanding, influenced by Virchow and Paget, reorients surgical strategies for better cancer treatment.
Area of Science:
- Surgical Oncology
- Cancer Biology
- History of Medicine
Background:
- Historically, neoplasms were thought to progress linearly, spreading locally before becoming systemic.
- This led to aggressive surgical interventions like Halsted's radical mastectomy, based on outdated concepts of tumor containment.
More Related Videos
Related Concept Videos
02:30Metastasis
6.1K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
6.1K
02:07Tumor Progression
6.9K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.9K
01:35Cancer Cell Migration through Invadopodia
2.6K
Invadosome is a broad category of cell surface structures with proteolytic activity that degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
2.6K