Related Experiment Video
Updated: Nov 23, 2025
Serial Two-Photon Tomography of the Whole Marmoset Brain for Neuroanatomical Analyses
Published on: January 17, 2025
Multimodal chemical imaging of a single brain tissue section using ToF-SIMS, MALDI-ToF and immuno/histochemical
Ibrahim Kaya1, Eva Jennische2, Stefan Lange2
1Department of Psychiatry and Neurochemistry, Sahlgrenska Academy at the University of Gothenburg, Mölndal Hospital, House V, S-43180 Mölndal, Sweden. ibrahim.kaya@farmbio.uu.se and Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg 412 96, Sweden and The Gothenburg Imaging Mass Spectrometry (Go:IMS) Platform, University of Gothenburg and Chalmers University of Technology, Gothenburg 412 96, Sweden. malmper@chalmers.se and Current affiliation: Medical Mass Spectrometry Imaging, Department of Pharmaceutical Biosciences, Uppsala University, BMC 591, Uppsala 751 24, Sweden.
Abstract:
Cluster ion beam ToF-SIMS and/or MALDI-ToF mass spectrometry imaging (using 1,5-DAN matrix via sublimation) of a single coronal rat brain tissue section followed by classical- or immuno- histochemical staining faclilated a new multimodal chemical imaging workflow allowing complementary correlation of the lipid molecular ion images with the immuno/histological features within cerebellum region of the same brain tisue section.
