Related Experiment Video
Updated: Nov 23, 2025
04:41
Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
Published on: July 28, 2023
3.0K
A hesitated approach: primary radiotherapy for keloids-a case series
Sezin Yuce Sari1, Melek Tugce Yilmaz1, Gozde Yazici2
1Department of Radiation Oncology, Hacettepe University Medical School, 06100, Ankara, Turkey.
Summary
Hypofractionated radiotherapy (RT) is a feasible treatment for resistant keloids. This study found complete remission in all patients with minimal, temporary side effects.
Area of Science:
- Dermatology
- Radiation Oncology
Background:
- Keloids are benign fibrous growths that can be challenging to treat, especially when resistant to standard therapies.
- Hypofractionated radiotherapy (RT) offers a potentially effective treatment modality for such cases.
Purpose of the Study:
- To evaluate the efficacy and toxicity of hypofractionated RT as a standalone treatment for patients with symptomatic, treatment-resistant keloids.
Main Methods:
- A cohort of six patients with 13 inoperable keloid lesions, unresponsive to prior treatments, received hypofractionated RT.
- Treatment involved a total dose of 37.5 Gy in five fractions using 6-MeV electrons or 6-MV photons.
- Patients were assessed for lesion characteristics and symptoms, with response graded as complete remission, partial remission, or stable disease.
Main Results:
- All patients achieved complete remission at the 6-month follow-up, with significant improvement in symptoms and lesion size.
- Patients reported satisfaction with cosmetic outcomes.
- Grade 2 dermatitis occurred in all patients during RT but resolved completely within 6 months post-treatment.
Conclusions:
- Hypofractionated RT, delivering 37.5 Gy in five fractions, is a feasible and effective treatment option for keloids resistant to conventional therapies.
- This RT regimen demonstrates a favorable safety profile with manageable and transient side effects.
